Assay Design Affects the Interpretation of T-Cell Receptor Gamma Gene Rearrangements
نویسندگان
چکیده
منابع مشابه
Diversity of T-cell receptor Gene Rearrangements in South Indian Patients with Common Acute Lymphoblastic Leukemia
Background: Precursor B-Acute Lymphoblastic Leukemia (precursor B-ALL) oc-curs due to the uncontrolled proliferation of B-lymphoid precursors arrested at a par-ticular stage of B-cell development. Precursor-B-ALL is classified mainly into pro-B-ALL, common-ALL and pre-B-ALL. The Common Acute Lymphoblastic Antigen CD10 is the marker for common-ALL. Objective: This study was aimed to examine the ...
متن کاملdiversity of t-cell receptor gene rearrangements in south indian patients with common acute lymphoblastic leukemia
background: precursor b-acute lymphoblastic leukemia (precursor b-all) oc-curs due to the uncontrolled proliferation of b-lymphoid precursors arrested at a par-ticular stage of b-cell development. precursor-b-all is classified mainly into pro-b-all, common-all and pre-b-all. the common acute lymphoblastic antigen cd10 is the marker for common-all. objective: this study was aimed to examine the ...
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The possibility to detect markers of T-cell clonality at the T-cell receptor (TCR) beta and gamma loci in skin biopsy samples has proven to be helpful for the often difficult clinical and immunohistochemical diagnosis of cutaneous T-cell lymphoma (CTCL). However, particularly at the early stage of the neoplastic infiltration, an emerging clonal pattern at Southern may be obscured by the germlin...
متن کاملThe distribution of gene segments in T-cell receptor gamma gene rearrangements demonstrates the need for multiple primer sets.
Limited data exist regarding the distribution of gene segments used in T-cell receptor gamma gene rearrangements (TCR gamma GR) in T-cell lymphoproliferative disorders. The reported efficacy of TCR gamma GR protocols ranges from 60% to greater than 90%. Laboratories reporting a lower detection rate tend to use a limited set of primers. The goal of our study was to provide TCR gamma GR data to d...
متن کاملImmunoglobulin and T-Cell Receptor Gene Rearrangements in Hodgkin's Disease1
We have examined tumor tissue DNA obtained from 32 cases of Hodgkin's disease of the following subtypes: lymphocyte predominance, six; nodular sclerosing, eight; mixed cellularity, 14; lymphocyte depleted, 4; using immunoglobulin and T-cell receptor ¡iand y gene probes. Immunoglobulin heavy chain rearrangements were detected in five pa tients; in three of them only a minor clonal cell populati...
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ژورنال
عنوان ژورنال: The Journal of Molecular Diagnostics
سال: 2010
ISSN: 1525-1578
DOI: 10.2353/jmoldx.2010.090183